Durable pain relief from a single MM-II injection and its cartilage-protective effects in OA models featured in two peer-reviewed articles -

- New data on MM-II to be presented this weekend at the OARSI 2025 World Conference on Osteoarthritis -

- MM-II recently granted Fast Track Designation by the US FDA -

Sun Pharma (Reuters: SUN.BO) (Bloomberg: SUNP IN) (NSE: SUNPHARMA) (BSE: 524715) (Sun Pharmaceutical Industries Limited, and includes its subsidiaries or associate companies) and Israel-based Moebius Medical Limited announced  the publication of two articles in Osteoarthritis and Cartilage, the official journal of the Osteoarthritis Research Society International (OARSI), highlighting MM-II, a novel non-opioid product for the treatment of symptomatic knee osteoarthritis.

MM-II is based on a proprietary suspension of large, empty, multilamellar liposomes designed to reduce joint friction and wear, thereby alleviating pain. The two publications offer complementary insights into MM-II's clinical efficacy and mechanism of action, underscoring its potential therapeutic value.

The first publication presents results from a Phase 2b randomized, double-blind, placebo-controlled trial (NCT04506463), which enrolled 397 patients across the US, Europe and Asia. Findings demonstrate that a single injection of MM-II provided clinically meaningful pain relief through 26 weeks, with a favorable safety and tolerability profile 

The second publication, titled "Empty large liposomes reduce cartilage degeneration in osteoarthritic rats by forming a lubricative coating," details MM-II's unique mechanism of action. The research shows that MM-II forms a lubricative layer over cartilage surfaces, reducing friction and slowing cartilage degeneration. The authors suggest that the results of the clinical trial may be mediated through the coating of the cartilage surfaces, though additional mechanisms may contribute to the long term pain reduction seen in Phase 2b study. [Link: https://doi.org/10.1016/j.joca.2025.02.774].

"The data from these publications show that MM-II has the potential to provide durable pain relief for patients," said Prof. Thomas J Schnitzer, MD, PhD, a rheumatologist and professor of Medicine at Northwestern University and lead author of the clinical trial manuscript. "With limited treatment options, lack of novel treatment approaches, and concerns around opioid use, MM-II may offer a promising alternative to hyaluronic acid and steroid treatments."

Moshe Weinstein, CEO of Moebius Medical, added: "Having both our clinical data and our research on MM-II's underlying mechanism of action published in the leading peer-reviewed journal for osteoarthritis further validates MM-II's novel treatment approach."

Coinciding with these publications, Sun Pharma and Moebius Medical are also presenting new data at the OARSI 2025 World Congress on Osteoarthritis taking place this week. Three abstracts were accepted for presentation at the congress, and the companies will also host a satellite symposium which exploring MM-II's mechanism of action, clinical data and planned phase 3 program.