Everest Medicines Announces New mRNA Rabies Vaccine Program and Achievement of Preclinical Proof-of-Concept Milestone

15 December 2022 | Thursday | News

Everest Medicines (HKEX 1952.HK, "Everest"), a biopharmaceutical company focused on developing and commercializing transformative pharmaceutical products that address critical unmet medical needs for patients in Greater China and other parts of Asia, announced today that the company has achieved the preclinical proof-of-concept milestone for its mRNA rabies vaccine program. This new vaccine candidate for rabies post-exposure prophylactic was developed in partnership with Providence Therapeutics Holdings Inc. ("Providence") utilizing a clinically validated mRNA technology platform.
Image Source : Public Domain

Image Source : Public Domain

Rabies program, as the first non-COVID19 vaccine developed with a specialized mRNA platform, highlights Everest's discovery capabilities

Clinically validated mRNA platform is shown to generate differentiated products across a range of indications

"The mRNA rabies vaccine program is an important validation of our discovery capability and the mRNA platform as the first of several non-COVID mRNA vaccine/therapeutics candidates," said Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines. "We continue to advance our Omicron-containing bivalent booster candidate, EVER-COVID19-M1.2, in China and other Everest territories and plan to initiate clinical trials in 2023. Building on the momentum of promising mRNA infectious disease vaccine candidates, we are well-positioned to continue innovating novel candidates using this mRNA technology platform across a wide range of disease indications."

In a head-to-head immunogenicity comparison study with a commercial inactivated rabies vaccine, mice dosed with Everest's pre-clinical rabies vaccine candidate produced higher levels of serum neutralizing antibodies than those of mice dosed with the comparator vaccine. Everest's candidate also induced a significantly higher degree of T-cell-mediated immune response than the comparator vaccine. These positive results support the clinical development of the rabies vaccine. Everest and Providence hold 50/50 global rights to develop and commercialize the new rabies vaccine.

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