20 April 2022 | Wednesday | News
Image Source : Public Domain
MVR-T3011, ImmVira's proprietary 3-in-1oncolytic herpes simplex virus ("oHSV"), is a novel genetically engineered oHSV which aims to achieve the most favorable profile of attenuated HSV-1 with replication potency in tumor cells. The incorporation of two latest and well-validated exogenous genes, PD-1 antibody and IL-12, further enhances immune responses in the tumor microenvironment. MVR-T3011 IT clinical trials started in 2020 and are currently in Phase II in both the U.S. and China. Single agent treatment has demonstrated good safety profile and preliminary efficacy results.
In 2021, ImmVira research group published a scientific paper, "Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models". In vitro and in vivo anti-tumor studies showed that, treatment with MEKi augmented oHSV oncolytic activity in BRAF V600E-mutated tumor cells and the combination treatment enhanced virus replication mediated by down-regulation of STAT1 and PKR expression or phosphorylation in BRAF V600E-mutated tumor cells as well as BRAF wt/KRAS-mutated tumor cells. Furthermore, a significant synergistic therapeutic efficacy was shown in vivo for BRAF wt/KRAS-mutated tumor models, when a combination of MEK inhibition and oHSV expressing PD-1 blockade antibody and IL-12.
"This combo clinical study further demonstrates the potential ability of MVR-T3011 to further extend clinical benefit to a wide range of approved treatment programs. This is also the first combination therapy other than checkpoint inhibitor of our core oncolytic products, and the first application of from scientific exploration to clinical studies. We are particularly pleased to collaborate with Roche with their leadership in the industry, global footprint and a deep pocket of established as well as novel programs driven by the inspiring purpose of doing now what patients need next," said Dr. Grace Zhou, CEO of ImmVira.
"Based on OvPENS new drug R&D platform, ImmVira will continue to push forward the envelope of vector-based oncology solutions. Leveraging a unique approach to modify the tumor environment, our pipeline of single agent and combo programs aims to become a new generation of safer and more effective therapies to address the increasingly complex cancer patients' needs worldwide."