Intellectual Property Portfolio Includes 39 Granted and Pending Patents in the U.S. and Internationally, Providing Protection Into 2041, Unless Extended Further

 MetaVia Inc. (Nasdaq: MTVA), a clinical-stage biotechnology company focused on transforming cardiometabolic diseases,  announced a strong global intellectual property portfolio supporting lead asset DA-1726, a novel, dual oxyntomodulin (OXM) analog agonist that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR), for the treatment of obesity and related metabolic disorders. This currently includes 39 granted and pending patents in the U.S. and internationally, providing protection into 2041, unless extended further.

MetaVia's patent portfolio, exclusively licensed from Dong-A ST Co., Ltd., provides broad protection covering the novel peptide structure of DA-1726 as well as its design as a long-acting dual-incretin therapy. Together, these protect both the core molecule and its therapeutic use in obesity, metabolic disease, and associated cardiometabolic conditions, strengthening the company's long-term development and commercialization position in one of the fastest-growing areas of medicine.

"Building a strong and durable patent foundation is essential as we advance DA-1726 as a potential best-in-class therapy for obesity and metabolic disease," stated Hyung Heon Kim, President and Chief Executive Officer of MetaVia. "Our intellectual property estate protects the unique design of this dual GLP-1/glucagon agonist and supports the long-term value of the program. As importantly, our recent clinical data reinforce the promise of DA-1726. At the 48 mg dose, we saw meaningful weight loss of about 9%, significant reductions in waist size, improvements in blood sugar levels, and early signs of direct liver benefit, all with a favorable safety profile."

Mr. Kim continued, "Looking ahead, our planned 16-week titration studies to 48 mg and 64 mg reflect our confidence in the therapy's tolerability and its potential to offer an advantage over the slower dose-escalation schedules required by current GLP-1 treatments. With results expected in the fourth quarter of 2026, we believe we are well positioned to unlock additional value as we advance DA-1726 into later-stage development."