23 June 2023 | Friday | News
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Further data from Telix's completed pivotal Phase III ZIRCON study of TLX250-CDx (89Zr-DFO-girentuximab) in clear cell renal cell carcinoma (ccRCC) (ClinicalTrials.gov Identifier: NCT03849118) will be delivered by Jeremie Calais, MD in an oral presentation.
In addition, Andrew M. Scott, MD will present a preclinical evaluation of Telix's CAIX-targeting radionuclide therapy candidate TLX250 (177Lu-DOTA-girentuximab) in combination with a Merck KGaA DNA-dependent protein kinase (DNA-PK) inhibitor candidate, peposertib.
SNMMI 2023 will also feature presentations on Telix's lutetium-based, antibody-directed prostate cancer therapy program, ProstACT, and the Company's FDA-approved, gallium-based prostate cancer imaging agent, Illuccix®, where PSMA imaging with positron emission tomography (PSMA-PET) continues to be a focus for the nuclear medicine and molecular imaging community.
Telix Chief Medical Officer, Dr. Colin Hayward said, "It is fantastic to have such broad representation at this year's SNMMI annual meeting, the premier educational, scientific, research, and networking event in nuclear medicine and molecular imaging worldwide. Alongside further data from the highly successful Phase III ZIRCON study in kidney cancer imaging, we are excited to present latest updates from our ProstACT SELECT and TARGET studies as this program builds momentum into the ProstACT GLOBAL study.
"Preclinical data from a study of Telix's CAIX-targeting therapy candidate TLX250 with an investigational DNA damage response inhibitor will also be presented as this combination prepares to move into the clinic. And last – but by no means least – our approved prostate cancer imaging agent, Illuccix, will feature on the program as part of lifecycle management. Drop by our booth number 4015 to meet with the team, to learn about Telix's deep theranostic pipeline, and to discuss how recent guideline updates for prostate cancer imaging could impact clinical decision making and patient management."
SNMMI oral presentation details are as follows:
Session: Focus on Clinical Studies – New Insights
Title: 177Lu-TLX591 safety, biodistribution and dosimetry study (ProstACT SELECT)
Date and Time: 24-Jun-2023, 3:45 – 3:55 PM
Presenter: Nat Lenzo, MD (GenesisCare)
Abstract ID: P1145
Session: Urologic Malignancies – Integrated Session
Title: 89Zr-DFO-girentuximab PET/CT imaging can accurately detect clear cell renal cell carcinoma (ccRCC) primary and secondary lesions in patients with renal masses at conventional imaging, results from ZIRCON Phase III study
Date and Time: 26-Jun-2023, 10:55 - 11:05 AM
Presenter: Jeremie Calais, MD (UCLA)
Abstract ID: P1113
Session: Imaging and Therapy in Preclinical Oncology Models – Session 2
Title: Addition of DNA dependent protein kinase (DNA-PK) inhibitor peposertib enhances efficacy of 177Lu-based radioimmunotherapy in pre-clinical models of prostate and renal cell carcinoma
Date and Time: 26-Jun-2023, 11:05 – 11:15 AM
Presenter: Andrew M. Scott, MD (Olivia Newton-John Cancer Research Institute, and La Trobe University)
Abstract ID: P1271
SNMMI poster presentations:
Session: Meet the Author: Oncology: Clinical Therapy & Diagnosis – Group A
Title: Analysis of bone lesions on 68Ga-PSMA-11 PET/CT in a randomized controlled trial of men with biochemical recurrence of prostate cancer post prostatectomy
Date and Time: 26-Jun-2023, 11:15 – 11:45 AM
Presenter: David Schuster, MD (Emory University)
Abstract ID: P968
Session: Meet the Author: Oncology: Clinical Therapy & Diagnosis – Group A
Title: External beam therapy with theranostic radioligand therapy for oligometastatic prostate cancer (ProstACT TARGET)
Date and Time: 26-Jun-2023, 11:15 – 11:45 AM
Presenter: Nat Lenzo, MD (GenesisCare)
Abstract ID: P1178
Session: Meet the Author: Oncology: Clinical Therapy & Diagnosis – Group A
Title: 30-second acquisition for Ga-68 PSMA-11 total-body PET/CT impacts prostate cancer management
Date and Time: 26-Jun-2023, 11:15 – 11:45 AM
Presenter: Harshad Kulkarni, MD (BAMF Health)
Abstract ID: P1408
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