GSK Announces Additional Supply of Monoclonal Antibody Sotrovimab to the SIngapore Govt.

07 December 2021 | Tuesday | News

GlaxoSmithKline Singapore announced an agreement with the Government of Singapore to supply additional doses of sotrovimab. Sotrovimab is an investigational single-dose monoclonal antibody developed in partnership with Vir Biotechnology, for the treatment of patients with COVID-19 who do not require oxygen supplementation and who are at risk of progressing to severe COVID-19. This follows the initial purchase agreement signed between GSK Singapore and the government in June 2021.
Image Source : Public Domain

Image Source : Public Domain

  • GSK Singapore is contracted to supply the Government of Singapore with additional doses of sotrovimab, following the first purchase placed by the Ministry of Health (MOH) in June 2021
  • Sotrovimab was approved by the Singapore Health Sciences Authority (HSA) under the Pandemic Special Access Route (PSAR) for interim authorization in June 2021

Priya Kudva Menon, VP and General Manager, GSK Singapore, said: "As we move into the endemic stage of COVID-19 in Singapore, it is clear that multiple treatment options are needed to manage the impact of this virus on people and communities, in addition to vaccinations and other preventative measures. We are proud to continue partnering with the Singapore government to supply our monoclonal antibody and to support Singapore's healthcare system as the country continues to open up."

Dr Leong Hoe Nam, infectious disease specialist, Rophi Clinic, Mount Elizabeth Novena Hospital, said: "Early treatment of patients with COVID-19 has been shown consistently to reduce the risk of progressing to severe disease. As we transition to endemic COVID-19, we would experience individuals who remain unvaccinated or do not mount a sufficient immune response following vaccination. Treatments like sotrovimab is an extremely useful armament in our fight against COVID-19. I'm glad to learn of the Singapore government's successful procurement of yet another effective treatment option. It will further protect and save the lives of many Singaporeans."

In June 2021, GSK Singapore signed the first purchase agreement with the MOH for the supply of sotrovimab. Sotrovimab also received interim authorization approval from the Singapore HSA under the Pandemic Special Access Route (PSAR) in June. 

GSK recently announced preclinical data that demonstrates sotrovimab retains activity against key mutations of the new Omicron SARS-CoV-2 variant (B.1.1.529), including those found in the binding site of sotrovimab. These data were generated through pseudo-virus testing of specific individual mutations found in Omicron. To date, sotrovimab has demonstrated ongoing activity against all tested variants of concern and interest defined by the World Health Organization (WHO). GSK and Vir are now completing in vitro pseudo-virus testing to confirm the neutralising activity of sotrovimab against the combination of all the Omicron mutations with the intent to provide an update by the end of 2021.

Sotrovimab was deliberately designed with a mutating virus in mind. By targeting a region of the spike protein that is shared between distantly related coronaviruses (including SARS, SARS-CoV-2 and animal sarbecoviruses), the sotrovimab binding site is less likely to mutate. 


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