04 November 2022 | Friday | News
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The clinical trial, entitled the "Safety and Efficacy of iPSC-derived Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients - the Nereid Study", will be led by Prof. Ton Rabelink, Head of the Department of Internal Medicine of LUMC and will seek to recruit 10 patients who have undergone a renal transplant. The trial is expected to commence in 2023, pending receipt of customary and relevant regulatory, ethics and administrative approvals.
Dr Ross Macdonald, Cynata's Chief Executive Officer, said:
"This exciting new collaboration follows very promising clinical trial data with MSCs published by Professor Rabelink and our own published pre-clinical data in organ transplant rejection. The potential to enhance survival of transplanted donor organs while at the same time reducing or eliminating the need for damaging anti-rejection drugs would be a substantial breakthrough in transplantation medicine. We are delighted to be working with one of Europe's leading transplant centres and with Professor Rabelink and his team to conduct this important clinical trial."
Professor Rabelink said:
"There is an urgent need for more effective management of immune rejection of donor organs while preserving organ function and minimizing side effects of anti-rejection therapy. From this perspective, MSC therapy is of interest and our own clinical studies have provided strong support for MSC treatment to substantially advance the field of transplantation medicine. The consistency and potency of Cynata's unique iPSC-derived Cymerus MSCs make them an ideal candidate for this clinical trial."