Ractigen Therapeutics Launches Pioneering Phase I Clinical Trial for Bladder Cancer with First Patient Dosed in Collaboration with GenesisCare

04 April 2024 | Thursday | News

The trial of RAG-01, an innovative saRNA therapy targeting NMIBC, begins in Australia, marking a significant step forward in the development of new cancer treatments.
Image Source : Public Domain

Image Source : Public Domain

Ractigen Therapeutics, a pioneer in small activating RNA (saRNA) therapeutics, achieved a major milestone with the first patient dosed in its First-in-human phase I clinical trial for RAG-01 conducted in collaboration with GenesisCare, Australia's leading provider of cancer care services. This marks a significant advancement in the fight against non-muscle invasive bladder cancer (NMIBC).

RAG-01 is a groundbreaking saRNA medication designed to combat bladder cancer by targeting and activating the p21 tumor suppressor gene in NMIBC. The trial is an open-label, multi-center study designed to assess RAG-01's safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy in NMIBC patients who have failed Bacillus Calmette-Guérin (BCG) therapy. Preclinical data indicates that RAG-01 effectively inhibits bladder cancer tumor growth in animal models and has shown a favorable safety profile. 

Dr. Long-Cheng Li, Founder and CEO of Ractigen Therapeutics, stated, "The successful administration of RAG-01 to the first patient underscores Ractigen's robust clinical translation capabilities, signifying an important milestone in our quest to develop innovative treatments for NMIBC patients and to prove the effectiveness of the saRNA platform in real-world applications."

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