Thermo Fisher Scientific has introduced the Thermo Scientific Sequential Protein DNA RNA Extraction Kit, a sample preparation solution designed to enable the sequential extraction of protein, DNA and RNA from a single biological sample. The kit addresses a persistent challenge in cancer and disease research, where samples are often limited, precious, and difficult to replace.
By enabling researchers to generate genomic and proteomic data from the same starting material, the kit supports more direct comparison of molecular findings across biological layers. This integrated approach helps scientists connect genetic variation, gene expression, and protein level activity without splitting scarce material across multiple workflows.
As research increasingly relies on small biopsies, rare cell populations, and other constrained specimens, the ability to maximise information from a single sample has become essential. The Sequential Protein DNA RNA Extraction Kit is designed to help researchers make more effective use of limited material while maintaining consistency across downstream analyses.
The purified protein generated using the kit is suitable for downstream mass spectrometry analysis, while extracted DNA and RNA are compatible with next generation sequencing applications. This compatibility enables researchers to align molecular data more directly and with greater confidence.
“What I really loved about the Sequential Protein DNA RNA Extraction Kit is how the magnetic bead workflow let me easily recover proteins, RNA, and DNA in solution without any centrifugation, automate the entire process if I wanted to, and use the purified material immediately for downstream applications,” said Dr Osamu Ohara, Head of the Department of Applied Genomics, Biophysics and Clinical omics at Kazusa DNA Research Institute, Japan.
The kit is based on a magnetic bead workflow that eliminates centrifugation steps, enabling a streamlined protocol that can be automated where required. This approach supports both manual and high throughput laboratory environments and reduces handling steps that may otherwise introduce variability.
The Sequential Protein DNA RNA Extraction Kit is intended for researchers studying cancer and disease biology, particularly in contexts where understanding the interplay between genomic, transcriptomic, and proteomic signals is critical. Such studies frequently rely on small or difficult to replace samples, including patient derived biopsies or rare cell subsets, making it challenging to conduct multiple molecular analyses from a single specimen.
“In cancer and disease research, samples often come from patients through procedures that can be difficult or invasive, and researchers may only have one opportunity to learn from them,” said Malin Karlsson, Senior Director and General Manager, CEP and Beads, Life Sciences Solutions Group at Thermo Fisher Scientific. “Being able to analyse protein, DNA and RNA from the same sample allows scientists to make the most of that material and better connect molecular changes, without having to choose one type of analysis over another.”
Key Applications
The kit supports cancer and disease research applications that seek to connect genetic variation, gene expression, and protein activity using small or limited biological samples. It is particularly suited to workflows requiring multiomic integration from a single specimen.
Features And Benefits
Single sample molecular analysis
Enables sequential extraction of protein, DNA and RNA from the same cell or tissue sample, helping researchers connect molecular signals across biological layers while making efficient use of limited material.
Compatibility with downstream analysis
Produces purified DNA and RNA suitable for next generation sequencing and protein suitable for mass spectrometry, supporting widely adopted genomic and proteomic research workflows.
Designed for limited and precious samples
Supports research involving small or difficult to replace samples such as biopsies or rare cell populations, where dividing material across multiple workflows may not be feasible.
With this launch, Thermo Fisher Scientific continues to expand its portfolio of sample preparation technologies designed to support multiomic research and help scientists accelerate insight in cancer and disease biology.
